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TDM Drug Dose Tables
The doses candidates tell us they cram every morning — organized by clinical area, taken from named Canadian sources, printable, and one click away from becoming spaced-repetition flashcards in your free account.
| Drug | Indication | Dose | Preg. | Lact. | Notes & cautions |
|---|---|---|---|---|---|
Ramipril 1st line | Hypertension | Initial 2.5 mg/day PO; usual 10 mg/day; max 20 mg/day (once daily or divided BID) | ✗ Avoid | — | Avoid: Avoid in bilateral renal artery stenosis, or unilateral stenosis with a solitary kidney → instead: In pregnancy the chapter's first-line agents are labetalol or nifedipine XL ACEi — first-line in single-pill combo with a thiazide |
Perindopril 1st line | Hypertension | Initial 4 mg/day PO; max 8 mg/day | ✗ Avoid | — | Avoid: Avoid in bilateral renal artery stenosis, or unilateral stenosis with a solitary kidney → instead: In pregnancy the chapter's first-line agents are labetalol or nifedipine XL ACEi |
Candesartan 1st line | Hypertension | Initial 8 mg/day PO; usual 8–16 mg/day, once daily | ✗ Avoid | — | Avoid: Avoid in bilateral renal artery stenosis, or unilateral stenosis with a solitary kidney → instead: In pregnancy the chapter's first-line agents are labetalol or nifedipine XL ARB — first-line in single-pill combo with a thiazide |
Losartan 1st line | Hypertension | Initial 50 mg/day PO; usual 25–100 mg/day; max 100 mg/day | ✗ Avoid | — | Avoid: Avoid in bilateral renal artery stenosis, or unilateral stenosis with a solitary kidney → instead: In pregnancy the chapter's first-line agents are labetalol or nifedipine XL ARB |
Amlodipine 2nd line | Hypertension | Initial 2.5 mg/day PO; max 10 mg/day, once daily | — | — | Avoid: CYP3A4 substrate — azole antifungals, protease inhibitors, macrolides, quinidine and grapefruit juice raise levels Long-acting DHP CCB — added as a third step after ARB + diuretic |
Hydrochlorothiazide 1st line | Hypertension | Initial 12.5 mg/day PO; usual 25 mg/day, once daily | ⚠ Caution | — | Avoid: Hypokalemia risk; choose another first-line agent if serious arrhythmia or prolonged QT → instead: Consider a loop diuretic in renal impairment Reserve >25 mg/day for resistant hypertension |
Chlorthalidone 1st line | Hypertension | Initial 12.5 mg/day PO; usual 12.5–25 mg/day, once daily | ⚠ Caution | — | Avoid: Hypokalemia risk; choose another first-line agent if serious arrhythmia or prolonged QT → instead: Consider a loop diuretic in renal impairment Thiazide-like diuretic |
Indapamide 1st line | Hypertension | Initial 1.25 mg/day PO; usual 2.5 mg/day, once daily | ⚠ Caution | — | Avoid: Hypokalemia risk; choose another first-line agent if serious arrhythmia or prolonged QT → instead: Consider a loop diuretic in renal impairment Thiazide-like diuretic |
Irbesartan/HCTZ 1st line | Hypertension — initial single-pill combination | Starting 150/12.5 mg once daily; may double after 4–6 wk if BP ≥130 systolic | ✗ Avoid | — | Avoid: Can exacerbate gout and diabetes → instead: In pregnancy the chapter's first-line agents are labetalol or nifedipine XL Example named initial combination; beta-blockers are NOT first-line without another indication |
Source: CPS — Hypertension (rev. Jan 6, 2026)
Pregnancy/Lactation flags reflect only what the named source chapter states — “—” means the chapter doesn't address it, not that the drug is safe or unsafe.
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Try 5 free questions →For exam preparation only. Doses are transcribed from the Canadian sources named on each table and simplified for study — always verify against the current product monograph and full guideline before any clinical use.